Table 3.
% Inhibition of α-Amylase Enzyme and IC50 Values of Heterocyclics Curcuminoid Analogs (8–16) and Standard Acarbose at Different Concentrations
| Synthesized Compounds | % of Inhibition (Mean ± S.D.)* (µg/mL) | IC50± SEM (µg/mL)a | |||
|---|---|---|---|---|---|
| 1.25 | 2.5 | 5 | 10 | ||
| 8 | 58.19±0.08 | 62.19±0.09 | 74.12±0.08 | 87.15±0.46 | 22.03±0.19 |
| 9 | 45.89±0.06 | 57.82±0.17 | 66.98±0.38 | 78.89±1.09 | 95.75±0.46 |
| 10 | 50.29±0.01 | 59.97±0.08 | 72.39±0.14 | 82.56±0.47 | 50.51±0.20 |
| 11 | 58.12±0.09 | 66.31±0.08 | 76.33±0.13 | 85.32±0.36 | 7.59±0.13 |
| 12 | 39.82±0.11 | 50.21±0.18 | 58.27±0.43 | 69.26±0.60 | 102.65±0.23 |
| 13 | 51.21±0.09 | 62.71±0.14 | 75.98±0.17 | 86.99±0.65 | 45.10±0.26 |
| 14 | 39.11±0.04 | 54.21±0.05 | 68.89±0.18 | 83.94±0.32 | 86.44±0.13 |
| 15 | 52.71±0.07 | 62.62±0.15 | 75.56±0.36 | 87.61±0.62 | 41.65±0.25 |
| 16 | 58.19±0.04 | 67.32±0.12 | 77.01±0.28 | 85.17±0.55 | 4.08±0.23 |
| Acarboseb | 57.38±0.36 | 67.99±0.47 | 77.99±0.56 | 85.78±0.45 | 8.01±0.08 |
| α-amylase | – | – | – | – | – |
Notes: *Values are expressed as mean ± SD (n=3). bAcarbose (Standard for α-amylase inhibitory activities).
Abbreviation: aSEM, standard error mean.