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. 2023 Jul 28;18:4253–4274. doi: 10.2147/IJN.S412932

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© 2023 Hsia et al.

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Evaluation of cell viability of MES-SA/Dx5 cells in the presence of different NP. (a) Cytotoxic effects of Dox or MSN on MES-SA or MES-SA/Dx5 seeded with a density of 5×10⁴ cells in 100 μL medium incubated with Dox only (0.4 or 5 μg/mL) or 50 μg/mL MSN. Data are the mean±SEM expressed as viability percentage relative to mock. *P<0.05 vs mock. (b) Combination treatment with Dox and TNFα on MES-SA/Dx5 cell line. (c) Seeded MES-SA/Dx5 cells were incubated with Dox (0.4 μg/mL) or different NP (50 μg/mL). Cell viability was quantified at various time points. Data are the mean±SEM expressed as viability percentage relative to mock. *P<0.05 at each time points.

Abbreviations: Dox, doxorubicin; MSN, mesoporous silica nanoparticles; TNFα, tumor necrosis factor alpha; MSN-Dox, PEG-MSN-Hydrazone-Dox; MSN-TNFα, TNFα-PEG-MSN; MSN-Dox-TNFα, TNFα-PEG-MSN-Hydrazone-Dox.