Figure 1.

The presence and extension of subclinical atherosclerosis in Progression of Early Subclinical Atherosclerosis participants is associated with epigenetic clocks predictive of time-to-death. (A) Odds ratio of the logistic regression models for the presence of subclinical atherosclerosis based on different imaging techniques: 3DVUS PVB (positive global plaque burden measured by 3DVUS); coronary artery calcium score (positive calcium score measured using computed tomography, Agatson); 2DVUS NT (at least one territory with plaque detected by 2DVUS) and PS (Progression of Early Subclinical Atherosclerosis score focal, intermediate or generalized vs. No disease). (B) Proportional odds-ratio of the ordinal logistic regression for the following categories of each imaging technique: 3DVUS PVB: Tertiles of 3DVUS global plaque volume as previously described³; CACS (0, 1–10, 10–100, >100); 2DVUS NT (number of territories with 2DVUS atherosclerotic plaque); PS (Progression of Early Subclinical Atherosclerosis Score: no disease, focal, intermediate, and generalized disease). * P < .05. All models were adjusted by diabetes, gender, smoking, dyslipidemia, obesity, family history of CVD, and hypertension. CACS, coronary artery calcium score; EAA, epigenetic age acceleration; OR, odds ratio; pOR, proportional odds-ratio.