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. 2023 Jun 20;44(29):2698–2709. doi: 10.1093/eurheartj/ehad361

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© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Progression of Early Subclinical Atherosclerosis individuals with accelerated grim epigenetic age have a higher predicted risk of having a cardiovascular event in 10 years and an increased cardiovascular age predicted by traditional cardiovascular risk scores. (A) Proportion of individuals with low atherosclerotic cardiovascular disease risk, borderline risk, medium risk, and high risk among individuals with accelerated, normal, or decelerated Grim epigenetic age. Chi² test P < .001. (B) Cardiovascular age derived from the Systematic Coronary Risk Evaluation algorithm calculated for individuals with accelerated, normal, and decelerated Grim epigenetic age (colour coded based on atherosclerotic cardiovascular disease risk score). ANOVA and t-test P-values are displayed. ASCVD, atherosclerotic cardiovascular disease; LR, low risk; BR, borderline risk; MR, medium; HR, high risk.