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Stringency control of eIF1 and eIF5 expression. Suboptimal AUG start codons of EIF1 mORF and inhibitory uORF in EIF5 mRNA sense global stringency of start codon selection: Low stringency enhances EIF1 mORF and EIF5 uORF translation, thereby increasing eIF1 and repressing eIF5 synthesis. High stringency increases leaky scanning over poor AUG codons, repressing EIF1 mORF and EIF5 uORF translation, thereby repressing eIF1 and increasing eIF5 synthesis.
