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Schematic model of AZIN1 translational control. (Top) Under low-polyamine conditions, most ribosomes leaky-scan over the near-cognate AUU start codon of the uCC uORF and translate the mORF. (Bottom) Polyamine-triggered pausing of a ribosome on the PPW motif in the uCC causes ribosomes to queue and enhances initiation at the near-cognate uCC start codon, repressing AZIN1 synthesis.
