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. 2023 Jun 1;37(11-12):490–504. doi: 10.1101/gad.350569.123

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© 2023 Abarinov et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 1. — Nkx2.2^SDmut/Cre animals develop overt neonatal diabetes. (A) Schematic highlighting amino acid conservation of the NK2-specific domain (SD). (B) Diagram of Nkx2.2 alleles used to generate Nkx2.2^SDmut/Cre mice. (C) NKX2.2 protein expression is similar in Nkx2.2^Cre/+ (WT/Cre) and Nkx2.2^SDmut/Cre (SDmut/Cre) pancreata at E18.5. (D) E18.5 Nkx2.2 mRNA expression remains unchanged among wild-type, heterozygous, and Nkx2.2^SDmut/Cre pancreata. (E,F) Body weight (E) and blood glucose levels (F) of P2 neonates. Data are presented as mean ± SEM. (ns) Not significant, (****) P < 0.0001. Scale bar, 50 µm.