Figure 5.

Disease severity and changes in microbiota observed in β7-deficient IL-10^-/- mice are recapitulated by IgA deficiency. A, Colon and cecum histological indices of disease severity of indicated genotypes at 8 to 12 weeks of age. B, Fecal bacterial counts from indicated strains determined via RT-qPCR for 16S rRNA expression. C, beta diversity principal coordinate analysis of the indicated mouse groups (mean ±S.D, from n > 10 mice in each data set.) Each data point represents an individual mouse. Statistical significance determined using one-way ANOVA, followed by Sidak multiple comparison test. From Tyler et al.⁶³