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. 2023 Mar 21;29(8):1327–1341. doi: 10.1093/ibd/izad024

Table 1.

Features of antibody secreting cells.a

Antibody Secreting Cells Plasmablast Plasma Cells
Lifespan + ++++
Proliferation ++ -
CD138, CXCR4 + +++
CD19, CD20, CD45,
MHC class II
++ +/-
1. Antibody secreting cells (ASC)- refers to proliferating plasmablasts and nonproliferating plasma cells.
2. Plasmablasts- Dividing ASC with migratory potential which may further mature into plasma cells.
3. Plasma cells (PC) - Terminally differentiated, non-replicating ASC able to secrete large amounts of antibodies.

a Table modified from Nutt et al in Nature Rev Immunol (2015) 15:160-171.