Table 1.
Antibody Secreting Cells | Plasmablast | Plasma Cells |
---|---|---|
Lifespan | + | ++++ |
Proliferation | ++ | - |
CD138, CXCR4 | + | +++ |
CD19, CD20, CD45, MHC class II |
++ | +/- |
1. Antibody secreting cells (ASC)- refers to proliferating plasmablasts and nonproliferating plasma cells. | ||
2. Plasmablasts- Dividing ASC with migratory potential which may further mature into plasma cells. | ||
3. Plasma cells (PC) - Terminally differentiated, non-replicating ASC able to secrete large amounts of antibodies. |
a Table modified from Nutt et al in Nature Rev Immunol (2015) 15:160-171.