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. 2023 Jul 24;12:e87169. doi: 10.7554/eLife.87169

Figure 1. Illustration of experimental data and the biophysical model for mouse primary visual cortex (V1).

Figure 1.

(A) Schematic of the experimental setup, with six Neuropixels probes inserted into six cortical (V1, latero-medial [LM], rostro-lateral [RL], antero-lateral [AL], postero-medial [PM], AM) and two thalamic areas (LGN, LP). (B) Top: spikes from many simultaneously recorded neurons in V1 during a single trial. Bottom: spikes from a single neuron recorded across multiple trials. In both cases, the stimulus was a full-field bright flash (onset at time 0, offset at 250 ms). (C) Top: local field potential (LFP) across all layers of V1 in response to the full-field bright flash, averaged over 75 trials in a single animal. Bottom: current source density (CSD) computed from the LFP with the delta iCSD method. (D) Histology displaying trace of the Neuropixels probe across layers in V1, subiculum (SUB) and dentate gyrus (DG). (E) Visualization of the V1 model with the Neuropixels probe in situ. (Image made using VND.)