Table 1.

Summary of five key studies for or against the accumulation of senescent cells in skeletal muscle with aging

Group	Study (Reference #)	Model	↑ SnC in Muscle	Markers	↑ SnC Genes	Genes/Proteins
Senescent cells accumulate in skeletal muscle with aging	Baker et al. (27)	Progeroid Mice	n/a	n/a	Yes	p16Ink4a, p21Cip1, p19Ink4d
	Baker et al. (28)	Genetically Modified Mice	n/a	n/a	Yes	p16Ink4a, p21Cip1, p19Ink4d
	da Silva et al. (50)	WT Mice	Yes	p21, TAF, HMGB1, LB1, SBB	n/a	n/a
	Xiong et al. (26)	Genetically Modified Mice	n/a	n/a	Yes	p16Ink4a
	Guzman et al. (49)	Genetically Modified Mice	Yes	SA β-Gal	Yes	p16Ink4a, p53
	Zhang et al. (39)	WT Mice and Humans	Yes	TAF, LB1,HMGB1, p16	Yes	p16Ink4a, p21Cip1
Senescent cells do not accumulate in skeletal muscle with aging	Jeyapalan et al. (63)	Primates	No	TAF, 53BP1	n/a	n/a
	Dungan et al. (59)	Humans	No	H2AX	n/a	n/a
	Yousefzadeh et al. (62)	Progeroid and WT Mice	n/a	n/a	No	p16Ink4a, p21Cip1
	Dungan et al. (36)	WT Mice	No	SA β-Gal	n/a	n/a
	Dungan et al. (61)	WT Mice	No	SA β-Gal, p21	n/a	n/a

SnC, senescent cell. Data delineates the results from whole muscle analysis of senescent cells or senescent cell gene expression, not the results from experiments performed on isolated SnCs. Markers is in reference to identification via histology.