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. 2023 Mar 8;146(8):3221–3231. doi: 10.1093/brain/awad078

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Two-step confirmatory test of the prognostic value of imaging measures in frontal regions. (A and B) The relationship between baseline levels of microglial activation in frontal regions (x-axis, [¹¹C]PK11195 BP_NDz-values) and annual rate of cognitive decline extracted from linear mixed-effects model on longitudinal cognitive scores (y-axis). (C and D) The relationship between baseline grey-matter (GM) volumes in frontal regions (x-axis, z-values) and annual rate of cognitive decline (y-axis). The shapes represent clinical diagnostic groups. Coefficients and P-values were obtained from inter-modality Spearman's correlation analyses.