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. 2023 Feb 9;146(8):3392–3403. doi: 10.1093/brain/awad038

Figure 2.

Figure 2

Shared loci between epilepsy and psychiatric disorders at conjFDR < 0.05. (A) Common genetic variants jointly associated with GGE and psychiatric disorders at conjFDR < 0.05. SCZ = schizophrenia; BIP = bipolar disorder; DEP = depression; Manhattan plots showing the −log10 transformed conjFDR values for each SNP on the y-axis and chromosomal positions along the x-axis. The dotted horizontal lines represent the threshold for significant shared associations [conjFDR <0.05, i.e. −log10(conjFDR) > 1.3]. Independent lead SNPs are circled in black. The significant shared signals in the MHC region are represented by one lead SNP only. For further information about the identified variants and loci, see Supplementary Tables 1–5. (B) Common genetic variants jointly associated with all epilepsy and schizophrenia and depression at conjFDR < 0.05. EP = all epilepsy. Manhattan plots showing the −log10 transformed conjFDR values for each SNP on the y-axis and chromosomal positions along the x-axis. The dotted horizontal lines represent the threshold for significant shared associations [conjFDR <0.05, i.e. −log10(conjFDR) > 1.3]. Independent lead SNPs are circled in black. The significant shared signals in the MHC region are represented by one lead SNP only. For further information about the identified variants and loci, see Supplementary Tables 7 and 8.