Table 2.
Pharmacokinetic Parameters of Apixaban 2.5 mg Twice Daily Among 10 PD Patients, Comparing Previous Multiple-Dose Study With HD Patients and Healthy Individuals
| Pharmacokinetic Parametersa | PD: Our study (2.5 mg twice a day) | HD: Mavrakanas et al7 (2.5 mg twice a day) | Healthy individuals: Frost et al21 (5 mg twice a day) |
|---|---|---|---|
| AUC0-12, ng h/mL | 2,574.4 (48.6%) | 1,009.8 (30.7%) | 1,051.9 (9%) |
| AUC0-infinite, ng h/mL | 10,034.4 (84.0%) | N/A | N/A |
| Cmax, ng/mL | 260.2 (44.7%) | 131.5 (31.1%) | 128.5 (10%) |
| Cmin, ng/mL | 180.2 (54.4%) | 58.0 (31.2%) | 49.6 (20%) |
| Tmax, h | 4.0 (28.9%) | 3.6 (48%) | 4.0 |
| t1/2, h | 25.2 (82.3%) | 7.5 (64.3%) | 11.7 (3.3) |
| Cl, ml/h | 481.7 (86.4%) | N/A | N/A |
Abbreviations: AUC, area under curve; Cl, clearance; Cmax, peak concentration; Cmin, trough concentration; HD, hemodialysis; t1/2, half-life; Tmax, time to reach Cmax; N/A, not available; PD, peritoneal dialysis.
a
Data expressed as mean (coefficient of variation).