Table 2.
Antibiotic alternatives | Type | Application | Treated birds | Mode of action | Effects | References |
---|---|---|---|---|---|---|
Organic acids | Organic acid-based product (Laynexa) |
Feed for 4 or 8 wk | Layer chickens | Improved gut pH | Showed no effect on egg weight and egg quality | Gama et al., 2000 |
Butyrate (0.4%) | Feed | Broiler chickens | Improved gut health | Maintained body weight gain |
Panda et al., 2009 |
|
Butyrate (0.2%) |
Feed | Broiler chickens | Improved gut health | Maintained the performance of birds | Leeson et al., 2005; Antongiovanni et al., 2007 | |
Mixture of 0.06% Galliacid, 0.1% Biacid |
Feed | Broiler chickens | Improved gut health | Improved birds’ performance | Hassan et al., 2010 | |
Organic acid mixture |
Feed | Layer chickens | Improved gut health | Showed no effect on the egg quality. However, egg weight was increased by 9.08% | Youssef et al., 2013 | |
Formic and butyric acids | Drinking water | Broiler chickens | Showed broad-spectrum antibacterial and antifungal activity | Showed no impact on birds’ performance. However, it improves the lymphoid organ weight |
Al-Mutairi et al., 2020 | |
Butyric acid, fumaric acid, and Lactic acid | Feed | Broiler chickens | Reduced pathogen multiplication | Improved birds’ performance | Adil et al., 2010 | |
Acetic acid |
Feed | Layer chickens | Improved gut health | Improved external egg quality as egg weight, egg length, egg diameter, and eggshell color | Kadim et al., 2008 | |
Organic |
Feed | Layer chickens | Increased the integrity of the reproductive organs, such as the shell gland in the oviduct | Improved eggshell color | Park et al., 2009 | |
1% lactic acid | Feed | Layer chickens | Increased the integrity of the reproductive organs | Improved the albumen and yolk index | Yalcin et al., 2000 | |
Microencapsulated feed additive including citric acid, sorbic acids, thymol, and vanillin | Feed | Broiler chickens | Lowered inflammation, and improved the intestinal barrier function | Improved chicken feed efficiency | Bialkowski et al., 2023 |