Figure 1.

Schematic representation of the experimental design. (a) Animals received oral afabicin (65 mg/kg) or clindamycin (100 mg/kg), linezolid (100 mg/kg), moxifloxacin (65 mg/kg) twice daily for 10 consecutive days (10d). (b) In the context of a DDI study, healthy volunteers received 20 days of oral treatment with afabicin 240 mg twice a day. For (a) and (b), faecal sampling was performed as indicated by triangles for 16S rDNA sequencing. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.