Table 1.
Criteria endorsed by professional societies and groups for the use of osteoanabolics in patients with osteoporosis. In many cases, denosumab and zoledronic acid are also endorsed
| Criterion | Society or group endorsing criterion | Refs |
|---|---|---|
| Very high fracture risk (various definitions) | AACE/ACE, NAMS, NOF/OP-Canada/ANMM, ESCEO/IOF, NOGG | [4••, 34, 36, 37, 38•] |
| Prior fracture | NAMS | [34] |
| Recent fracture | AACE/ACE, NAMS | [4••, 34] |
| Multiple fractures | AACE/ACE | [4••] |
| History of severe osteoporotic fracture | ENDO | [33] |
| History of vertebral fracture | ASBMR | [6••] |
| Recent vertebral fracture | NOGG | [38•] |
| Multiple vertebral fractures | ENDO | [33] |
| Multiple vertebral fractures or hip fracture and spine or hip T-score ≤ − 2.5 | BHOF | [35•] |
| History of hip fracture | ASBMR | [6••] |
| Recent hip fracture | NOGG | [38•] |
| Fracture while taking drugs that harm bone | AACE/ACE, NOGG | [4••, 38•] |
| Recent fracture while on glucocorticoids | NOGG | [38•] |
| Fracture while on approved OP therapy | AACE/ACE, NAMS | [4••, 34] |
| Bone loss while on antiresorptive therapy | NAMS | [34] |
| High risk of falls | AACE/ACE | [4••] |
| History of injurious falls | AACE/ACE | [4••] |
| Very high fracture probability by FRAX® | AACE/ACE | [4••] |
| BMD T-score below − 3.0 | AACE/ACE, NAMS | [4••, 34] |
| BMD T-score below − 2.5 with fracture history | ENDO | [33] |
| Patient with OP undergoing spinal instrumentation | AANS/CNS | [39•] |
| Adult with OP undergoing elective spine surgery | Expert multidisciplinary consensus panel | [40•] |
OP, osteoporosis; NOF, National Osteoporosis Foundation; OP-Canada, Osteoporosis Canada; ANMM, Academia Nacional de Medicina de Mexico; AACE, American Association for Clinical Endocrinology; ACE, American College of Endocrinology; NAMS, North American Menopause Society; ESCEO, European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases; IOF, International Osteoporosis Foundation; NOGG, National (UK) Osteoporosis Guideline Group; ASBMR, American Society for Bone and Mineral Research; ENDO, Endocrine Society; BHOF, Bone Health and Osteoporosis Foundation; AANS, American Association of Neurological Surgeons; CNS, Congress of Neurological Surgeons