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. 2023 Aug 1;14:4620. doi: 10.1038/s41467-023-40327-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Food intake of hepatocyte-specific conditional knockin (cKI) and WT male mice after 16 weeks of NC or HFD feeding (n = 7). b Body weight in indicated groups (WT, n = 9; cKI, n = 9; WT-HFD, n = 10; cKI-HFD, n = 10). c Epididymal fat weight (n = 8). d LW/BW ratio (WT, n = 9; cKI, n = 9; WT-HFD, n = 10; cKI-HFD, n = 10). e, f TG and TC content in the indicated groups (WT, n = 9; cKI, n = 8; WT-HFD, n = 10; cKI-HFD, n = 8). g H&E staining of liver sections (n = 8). Scale bar = 50 μm. Magnification 200×. h Oil red O staining of liver sections (n = 8). Scale bar = 50 μm. Magnification 200×. i Fasting blood glucose (WT, n = 9; cKI, n = 9; WT-HFD, n = 10; cKI-HFD, n = 10). j Fasting insulin levels (n = 8). k HOMA-IR index (n = 8). l GTTs (n = 9). m AUC of GTT (n = 9). n ITTs (n = 9). o AUC of ITT (n = 9). p mRNA levels of inflammatory cytokines in the livers (WT, n = 6; cKI, n = 7; WT-HFD, n = 6; cKI-HFD, n = 6). p values obtained via one-way ANOVA with Tukey’s multiple comparisons test. The data were shown as means ± SD of independent biological replicates. Source data are provided as a Source data file. LW/BW, liver weight/body weight. TG, Triglyceride. TC, Total cholesterol. n.s., not significant.