Table 2.
Frequency distribution of neurodegenerative patterns across clinical groups.
| Neurodegeneration Patterns α-synuclein related |
Atypical patterns |
|||||
|---|---|---|---|---|---|---|
| DLB-like | MSA-like | Typical PD-like | AD-like | FTD-like | CBD-like | |
| iRBD (N = 51) | 31 | 5 | 15** | 0 | 0 | 0 |
| PD-LDR (N = 28) | 0 | 0 | 28 | 0 | 0 | 0 |
| PD-HDR (N = 16) | 7 | 0 | 1 | 5 | 2 | 1 |
| DLB (N = 67) | 61 | 0 | 0 | 5 | 0 | 1 |
| MSA (N = 11) | 0 | 11 | 0 | 0 | 0 | 0 |
N = numbers; DLB: Dementia with Lewy Bodies; MSA: Multiple System Atrophy; PD: Parkinson's disease; PD-LDR: PD with low risk of dementia; PD-HDR: PD with high risk of dementia; iRBD: isolated REM sleep behaviour disorder; AD: Alzheimer's disease; FTD: Frontotemporal Dementia; CBD: Corticobasal degeneration.
*15 iRBD showed almost negative SPM single-subject maps. For classification purposes, we included the negative scan under the typical PD-like definition considering the strong topographical similarity. Of course, we cannot exclude the absence of neurodegenerative diseases for iRBD patients see discussion.