Table 2.
Gene-level association results.
| Symbol | Gene name | Variants | Total carriers | P value | FDR Q | Depth of coverage | ||
|---|---|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | Cases | Controls | |||||
| ZNF248 | Zinc Finger Protein 248 | 7 | 18 (12.1) | 52 (2.6) | 3.4E−06 | 0.0418 | 52 | 37 |
| PRKRA | Protein Activator of Interferon-Induced Protein Kinase | 5 | 27 (18.1) | 137 (6.9) | 1.1E−05 | 0.0418 | 121 | 176 |
| PYHIN1 | Pyrin and HIN Domain Family Member 1 | 10 | 15 (10.1) | 67 (3.4) | 1.1E−05 | 0.0418 | 43 | 40 |
| SLC7A8 | Solute Carrier Family 7 Member 8 | 7 | 9 (6) | 40 (2.0) | 1.2E−05 | 0.0418 | 43 | 46 |
| STK19 | Serine/Threonine-Protein Kinase 19 | 3 | 9 (6) | 12 (0.6) | 1.8E−05 | 0.0495 | 45 | 35 |