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. 2023 Jul 3;55(7):1357–1370. doi: 10.1038/s12276-023-01020-1

Table 1.

The regulatory role of noncoding RNAs in cancer cells.

Noncoding RNAs Roles in cancer Cancer Reference
MiRNA MiR-431-5p Inhibits tumor progression PDAC 108
MiR-601 Promotes cell proliferation by inhibiting the expression of TINP1 GBM 109
MiR-30d Targets the transcription factor RUNX1 and inhibits the transcriptional activation of the RUNX1-induced Warburg effect PDAC 113
MiR-21-3p Promotes cell growth and metastasis Liver cancer 114
MiR-378a Inhibits PCa cell proliferation Prostate cancer 115
MiR-612 Suppresses HCC cell invasion and migration HCC 116
MiR-4646-5p Promotes metastasis GC 117
LncRNA LncRNA H19 Promotes the growth of oral tumors Oral cancer 119
LncRNA ENO1-IT1 Promotes glycolysis and tumorigenesis CRC 120
LncRNA NRCP Promotes cancer cell growth Ovarian cancer 121
LINC00842 Leads to a metabolic switch from mitochondrial oxidative catabolic processes to fatty acid synthesis, enhancing the malignant phenotype of PDAC cells PDAC 122
LncRNA ropm Regulates the properties of breast cancer stem cells (BCSCs) by mediating lipid metabolism Breast cancer 123
Promotes the survival of glucose-deficient hepatoma cells by activating the serine synthesis pathway HHC 124
LINC00467 Promotes cell proliferation CRC 125
Lnc-NA Regulates the expression of the nuclear receptor NR4A1 and then increases caspase signaling pathway activation, promoting apoptosis in endometrial cell lines EC 126
CircRNA CircRPN2 Increases the expression of FOXO1 to suppress glucose metabolism and tumor progression HCC 130
CircMAT2B Promotes glycolysis through the activation of circMAT2B/miR-338-3p/PKM2 axis to promote HCC progression under hypoxic conditions HCC 131
CircEZH2 Promotes tumorigenesis and metastasis by sponging miR-217-5p and establishing a new feedback loop consisting of FUS/circEZH2/KLF5 Breast cancer 132
CircECE1 Interacts with c-Myc to prevent POZ-mediated c-Myc ubiquitination and degradation OS 133
CircErbin Promotes angiogenesis by increasing the expression of HIF-1α CRC 135
CircRNF13 Inhibits proliferation and metastasis NPC 136
CircFNDC3B Inhibits tumor progression by encoding the protein CircFNDC3B-218aa Colon cancer 138