FIGURE 7.

TRIM29 expression is correlated with clinical stage and TRIM29 is hypomethylated in patient nasopharyngeal swab DNA. (A) Representative images from immunohistochemistry analysis of TRIM29 expression in nasopharyngeal carcinoma (NPC) tissues. The brown granules in cytoplasm were considered as TRIM29‐positive staining. The staining intensity was scored as follows: 0, no staining; 1+, mild staining; 2+, moderate staining; and 3+, intense staining. Scale bar, 50 μm. (B) Spearman's rank correlation test was used to determine the correlation between TRIM29 staining and clinical stages. (C) Pyrosequencing of methylation status of CpG island of TRIM29 in DNAs from NPC and control swab samples; graph shows the combined data (normal, n = 13; NPC, n = 13). (D) Receiver operating characteristic (ROC) curve of TRIM29 methylation for the discrimination between NPC and normal control. **p < 0.01. AUC, area under the ROC curve.