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. 2023 May 25;114(8):3190–3202. doi: 10.1111/cas.15851

FIGURE 1.

FIGURE 1

Higher expression level of procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 2 (PLOD2) in colorectal carcinoma (CRC) is associated with poorer clinical survival factors. (A) Protein expression of PLOD2 in normal colorectal epithelial cells and CRC cells. (B) The PLOD2 mRNA expression in normal colorectal epithelial cells and CRC cells. (C) Protein expressions of PLOD2 in 18 paired normal colorectal epithelial tissues (N) and CRC tissues (T). (D) PLOD2 mRNA expressions in 32 paired normal colorectal epithelial tissues and CRC tissues. (E) Representative immunohistochemistry (IHC) staining of PLOD2 in paraffin‐embedded CRC tissues and their adjacent normal tissues with three different degrees of differentiation. [Case 1]: Good, [Case 2]: Moderate, [Case 3]: Poor. Scale bar 50 μm; and 20 μm in the enlarged image. (F) IHC staining score of normal and malignant colorectal epithelial tissues. (G) Percentage of non‐metastatic and metastatic CRC tissues in the group with low and high PLOD2 levels. (H) staining score of CRC cases classified into T1–2 stage and T3–4 stage. (I) Kaplan–Meier curve depicting the overall survival (top) and relapse‐free survival (bottom) of PLOD2 for CRC patients. The error bars represent mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.