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. 2023 May 25;114(8):3190–3202. doi: 10.1111/cas.15851

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© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 2 (PLOD2) enhances the proliferative and invasive abilities in colorectal carcinoma (CRC) cells in vitro. (A) Overexpression of PLOD2 was verified at the level of protein. (B) Downregulation of PLOD2 was confirmed at the protein level. (C, D) Upregulation of PLOD2 promoted the proliferation ability of CRC cells detected by CCK8 assays (C) and colony formation (D), while the silence of PLOD2 suppressed it (N = 3). (E, F) Upregulation of PLOD2 promoted the invasion ability of CRC cells detected by transwell assays (E, scale bar 50 μm) and scratch healing assays (F, scale bar 100 μm), while the silence of PLOD2 inhibited it (N = 3). The error bars represent mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.