Figure 3.

Regulated pathways

The 376 differentially abundant proteins identified from the discovery phase were submitted to function enrichment analysis with DAVID using the KEGG annotation. The heatmap shows the proteins enriched for each pathway. Asterisks mark those proteins in specific comparisons that were statistically significant. Comparison I1: time point(s) before seroconversion of the group that remained in autoimmunity by the age of 6 years (IA group) paired against matched controls. Comparison T1: time point(s) before seroconversion of the group that developed T1D by the age of 6 years (T1D group) paired against matched controls. Comparisons I2 and T2 have the same group of individuals as I1 and T1, respectively, but after seroconversion. Comparisons I3 and T3 compare IA and T1D groups before vs. after seroconversion, respectively.