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View full-text article in PMC

. 2023 Jun 29;4(7):101093. doi: 10.1016/j.xcrm.2023.101093

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Summary of pathways regulated in autoimmunity and T1D development

Many components of the complement cascade were found to be increased pre-seroconversion (comparisons T1/I1) and decreased post-seroconversion (T2/I2). An increase in phago/lysosome components was observed in comparisons T1/I1/T2. However, an increase in proteasome and antigen presentation components was only observed in T1. This process can trigger cellular signaling along with the stimulation of cytokine/chemokine receptors, regulating gene expression and cell metabolism (I1/T2/I2). We also observed a regulation of the extracellular matrix proteins (up in T1/I1/T2 and down in I2), which can regulate the interaction with immune cells. Comparison I1: time point(s) before seroconversion of the group that remained in autoimmunity by the age of 6 years (IA group) paired against matched controls. Comparison T1: time point(s) before seroconversion of the group that developed T1D by the age of 6 years (T1D group) paired against matched controls. Comparisons I2 and T2 have the same group of individuals as I1 and T1, respectively, but after seroconversion. Comparisons I3 and T3 compare IA and T1D groups before vs. after seroconversion, respectively.