Figure 5.

Construction of the three-dimensional PMR stratification for evaluating individual metabolic heterogeneity

(A) Distribution of the three PMR indexes (index 1–3) among the five subgroups (RFN0–RFN4) classified according to the present number of traditional risk factors.

(B) Mean scores of these three indexes (index 1–3) in the HC, pre-MetS, and MetS groups.

(C) Specific PMR patterns for all participants in the general population cohort. Gray, blue, and purple dots indicate individual status ranked by LMR, MMR, and HMR patterns, respectively.

(D) The relative changes in high-density lipoprotein cholesterol (HDLC), serum creatinine (SCr), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), uric acid (UA), body mass index (BMI), glucose (GLU), and triglycerides (TGs) in the MMR and HMR groups compared with those in the LMR group.

(E) Mean scores for index 1 (in gray) and index 3 (in purple) in the five MetS subtypes (RF1110, RF1011, RF1101, RF0111, and RF1111) and the HC group (RF0000).

(F) Cumulative curves and forest plots of the 4-year mortality events for 13,554 patients with three PMR statuses stratified by gender and age. The p value for multivariate Cox regression analysis models was calculated by the likelihood test. The p value for variables was obtained by a log-rank test and hazard ratio (HR).