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. 2023 Jun 21;4(7):101092. doi: 10.1016/j.xcrm.2023.101092

Figure 5.

Figure 5

Identification of TLS-interacting CNA targets in ovarian cancer (TICTOC)

(A) The association between CNA and hazard ratio of TLS when can/TLS interaction is greater than 1 (red) or less than 1 (blue).

(B) Volcano plot showing CNAs that are statistically interacting with TLS in the multivariable Cox regression model for overall survival in the TCGA cohort.

(C) Potential druggability of TICTOC targets.

(D–G) Kaplan-Meier plots showing association between TLS and overall survival when DCAF15 is not amplified in (D) the TCGA cohort and (F) the HH cohort and when DCAF15 is amplified in (E) the TCGA cohort and (G) the HH cohort. The p-values are given by log rank test.

(H) Correlation between DCAF15 expression and its copy-number alterations in the TCGA ovarian cancer cohort. Boxplot elements are defined as follows: the center line indicates median value, box limits indicate upper and lower quartiles, whiskers extend to 1.5× the interquartile range, and points beyond the whiskers are outliers.