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. 2023 Jul 19;11:1227723. doi: 10.3389/fcell.2023.1227723

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Copyright © 2023 Brauer, Merino-Veliz, Ahumada-Marchant, Arriagada and Bustos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Memory formation is significantly impaired in KMT2C bKO animals. (A) Percentage of time spent freezing by Control and KMT2C animals in the contextual fear conditioning test. (B) Quantification of the total distance travelled in the Barnes maze apparatus. (C) Primary latency of Control and KMT2C bKO animals in the Barnes maze apparatus. (D) Quantification of the time spent in the zone of interest where the escape hole was formerly located. Bars represents mean ± SEM; **p < 0.01, ***p < 0.001. Students t-test, n = 14 Control animals and n = 9 KMT2C bKO animals.