Table 1.

Screening of differential metabolites from MCAO and MACO + LTC.

No.	tR (min)	Description	m/z	Surgery _Pa	Medicationb (P < 0.05)	Surgery - Medication	VIP	Fold change c	Youden index
1	1.52	N1-Methyl-4-pyridone-3-carboxamide	153.0657 ([M+H]+)	0.994	0.005	0.525	2.4	1.6	0.778
2	1.59	Stearoyl sphingomyelin	731.6049 ([M+H]+)	0.138	0.018	0.124	4.2	0.5	0.833
3	6.03	Trichloroethanol glucuronide	346.9459 ([M+H]+)	0.112	0.005	0.233	4.8	2	0.63
4	8.03	Sulfolithocholylglycine	512.2685 ([M−H]−)	0.28	0.024	0.278	8.2	0.3	0.759
5	8.91	Ganodermic acid TQ	533.3257 ([M+H]+)	0.055	0.027	0.051	2.6	0.2	0.685
6	8.97	Taurohyocholate	514.2841 ([M−H]−)	0.094	0.041	0.076	16.5	0.2	0.759
7	9.28	LysoPC(20:5)	542.3240 ([M+H]+)	0.645	0.012	0.24	3.6	1.6	0.944
8	9.30	LysoPC [18:3(9Z,12Z,15Z)]	518.3242 ([M+H]+)	0.645	0.012	0.24	3.6	1.6	0.722
9	12.37	SM(d16:1/20:1)	729.5899 ([M+H]+)	0.106	0.004	0.081	3.3	0.6	0.778
10	13.87	PE(24:1/18:3)	824.6154 ([M+H]+)	0.112	0.025	0.545	2.3	1.4	0.778
11	14.08	SM(d18:1/20:0)	759.6371 ([M+H]+)	0.113	0.01	0.111	3	0.5	0.759
12	14.49	DG(16:1n7/0:0/18:1n9)	615.4956 ([M+H]+)	0.756	0.033	0.488	3.4	1.6	0.704
13	15.47	DG(20:0/0:0/14:1n5)	617.5112 ([M+H]+)	0.405	0.02	0.608	2	1.6	0.778

Note: ^a Surgery: (sham) + (sham + LTC) vs (MCAO + LTC) + (MCAO + LTC); ^b Medication: (sham) + (MCAO) vs (sham + LTC) + (MCAO + LTC); ^c MCAO + LTC vs MCAO.