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. 2023 Jul 19;14:1208780. doi: 10.3389/fphar.2023.1208780

FIGURE 2.

FIGURE 2

NSP Activities in Bone Marrow of (A–C) C57BL/6 and (D–F) BALB/c Mice Administered 7-Day Repeated Doses of Brensocatib. Reported NSP activities are 16 and 24 h post final BID and QD dose, respectively. Data are the plotted as mean ± SEM (n = 4, except for mid and high C57 QD groups where n = 6; and C57 NE and PR3 mid-dose BID and CatG low dose brensocatib BID where n = 3 due to outlier which was determined by Grubb’s test). *, p < 0.05 vs. vehicle; **, p < 0.01 vs. vehicle; ***, p < 0.001 vs. vehicle; ****, p < 0.0001 vs. vehicle; #, p < 0.05 vs. BID-QD.