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. 2023 Jul 19;14:1208780. doi: 10.3389/fphar.2023.1208780

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Copyright © 2023 Basso, Chen, Zhou, Mark, LaSala, Dorfman, Atalla, Chun, Viramontes, Chang, Leifer, McDonald and Cipolla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bensocatib Plasma Concentration from Repeated Dose Administration of Brensocatib by Oral Gavage. (A) BID in Sprague Dawley (SD) rats, (B) QD in SD rats, (C) BID in Wistar rats, (D) QD in Wistar rats. Data are plotted as mean ± SEM (n = 4, except for 0.2 mpk/day BID for SD at 1, 3, 9, and 24 h where n = 3; 2 mpk/day BID at 11 h for SD where n = 3; 0.3 mpk/day QD at 3 h for SD where n = 3; 3 mpk/day BID for SD at 3 and 24 h where n = 3; 30 mpk/day BID at 7.5 h for SD where n = 3; 0.2 mpk/day BID at 16 h for Wistar where n = 3; and 30 mpk/day QD at 8 h for Wistar where n = 3). mpk/day = mg/kg/day.