TABLE 1.

PK parameters of brensocatib in C57BL/6 and BALB/c mice during the first 24 h of BID or QD dosing.

		BID			QD
C57BL/6	Dose (mg/kg/day)	0.5	2	20	0.75	3	30
	AUC0–24h (ng•h/mL)	294 ± 49	2012 ± 154	15,866 ± 3505	735 ± 108	2843 ± 302	52,565 ± 6720
	AUC(0–24) (µmol•h/L)	0.70 ± 0.12	4.79 ± 0.37	37.73 ± 8.33	1.75 ± 0.26	6.76 ± 0.72	125.01 ± 15.98
	t1/2 (h), AM dose	0.71 ± 0.23	2.07 ± 0.42	2.41 ± 0.42	9.62 ± 0.95	6.38 ± 0.56	3.01 ± 0.18
	t1/2 (h), PM dose	0.63 ± 0.01	2.35 ± 0.35	2.36 ± 0.05	n/a	n/a	n/a
BALB/c	Dose (mg/kg/day)	0.2	2	20	0.3	3	30
	AUC0–24h (ng•h/mL)	124 ± 31	1508 ± 395	24,105 ± 4779	188 ± 31	2964 ± 679	56,303 ± 17,303
	AUC(0–24) (µmol•h/L)	0.29 ± 0.07	3.59 ± 0.94	57.32 ± 11.36	0.45 ± 0.07	7.05 ± 1.61	133.90 ± 41.15
	t1/2 (h), AM dose	1.58 ± 0.72	3.22 ± 0.35	2.47 ± 0.31	0.97 ± 0.03	0.83 ± 0.03	2.56 ± 0.14
	t1/2 (h), PM dose	0.67 ± 0.04	1.19 ± 0.34	1.88 ± 0.06	n/a	n/a	n/a

AUC, area under the concentration-time curve; t_1/2 = half life. Data are presented as mean ± SEM (n = 4, except for C57 20 mg/kg/day where n = 3, C57 3 mg/kg/day and 30 mg/kg/day where n = 6, and Balb/c 2 mg/kg/day where n = 3). n/a, not applicable.