TABLE 2.
Brensocatib treatment percentage change from vehicle control for BID and QD dosing in C57BL/6 and BALB/c mice. p-values derived from Sidak’s multiple comparison test.
| Change From Vehicle Control (%) | |||||
|---|---|---|---|---|---|
| NE | PR3 | CatG | |||
| C57BL/6 | BID | 0.5 mg/kg/day Brensocatib | −20% (p = 0.1494) | 9% (p = 0.8059) | −16% (p = 0.1964) |
| 2 mg/kg/day Brensocatib | −71% (p < 0.0001) | −44% (p = 0.0041) | −71% (p < 0.0001) | ||
| 20 mg/kg/day Brensocatib | −85% (p < 0.0001) | −80% (p < 0.0001) | −94% (p < 0.0001) | ||
| QD | 0.75 mg/kg/day Brensocatib | −9% (p = 0.8092) | +2% (p = 0.9977) | −1% (p = 0.9999) | |
| 3 mg/kg/day Brensocatib | −55% (p < 0.0001) | −46% (p = 0.0008) | −64% (p < 0.0001) | ||
| 30 mg/kg/day Brensocatib | −71% (p < 0.0001) | −65% (p < 0.0001) | −87% (p < 0.0001) | ||
| BALB/c | BID | 0.2 mg/kg/day Brensocatib | +26% (p = 0.4425) | +13% (p = 0.6435) | −1% (p = 0.9993) |
| 2 mg/kg/day Brensocatib | −23% (p = 0.5256) | −26% (p = 0.1243) | −36% (p = 0.0165) | ||
| 20 mg/kg/day Brensocatib | −79% (p = 0.0008) | −70% (p < 0.0001) | −92% (p < 0.0001) | ||
| QD | 0.3 mg/kg/day Brensocatib | −3% (p = 0.9990) | −7% (p = 0.9149) | −2% (p = 0.9983) | |
| 3 mg/kg/day Brensocatib | −16% (p = 0.8297) | −13% (p = 0.6769) | −39% (p = 0.0058) | ||
| 30 mg/kg/day Brensocatib | −46% (p = 0.0959) | −52% (p = 0.0010) | −84% (p < 0.0001) | ||