TABLE 5.
Brensocatib treatment percentage change from vehicle control for BID and QD dosing in Sprague Dawley and Wistar rats. p-values derived from Sidak’s multiple comparison test.
| Change From Vehicle Control (%) | |||||
|---|---|---|---|---|---|
| NE | PR3 | CatG | |||
| Sprague Dawley | BID | 0.2 mg/kg/day Brensocatib | +6% (p = 0.6846) | +23% (p = 0.8292) | +4% (p = 0.9857) |
| 2 mg/kg/day Brensocatib | −18% (p = 0.0243) | −31% (p = 0.6727) | +2% (p = 0.9972) | ||
| 20 mg/kg/day Brensocatib | −38% (p < 0.0001) | −68% (p = 0.0907) | −37% (p = 0.0420) | ||
| QD | 0.3 mg/kg/day Brensocatib | −2% (p = 0.9973) | −34% (p = 0.4869) | −9% (p = 0.9235) | |
| 3 mg/kg/day Brensocatib | −19% (p = 0.2196) | −59% (p = 0.0837) | −13% (p = 0.8203) | ||
| 30 mg/kg/day Brensocatib | −36% (p = 0.0078) | −72% (p = 0.0285) | −43% (p = 0.0348) | ||
| Wistar | BID | 0.2 mg/kg/day Brensocatib | −6% (p = 0.9661) | +10% (p = 0.9848) | −14% (p = 0.7146) |
| 2 mg/kg/day Brensocatib | −6% (p = 0.9676) | +22% (p = 0.8768) | −16% (p = 0.6392) | ||
| 20 mg/kg/day Brensocatib | −19% (p = 0.4767) | −46% (p = 0.4135) | −32% (p = 0.1106) | ||
| QD | 0.3 mg/kg/day Brensocatib | +8% (p = 0.9636) | +6% (p = 0.9963) | +5% (p = 0.9843) | |
| 3 mg/kg/day Brensocatib | +17% (p = 0.7823) | −35% (p = 0.5635) | −35% (p = 0.0605) | ||
| 30 mg/kg/day Brensocatib | −19% (p = 0.7283) | −59% (p = 0.1437) | −41% (p = 0.0202) | ||