TABLE 6.

Statistical comparison of BID vs. QD percentage change from vehicle at matched dosing levels in Sprague Dawley and Wistar rats. p-values derived from Sidak’s multiple comparison test.

		NE	PR3	CatG
SD	Low Dose Brensocatib	0.6794	0.1760	0.7615
	Mid Dose Brensocatib	0.9967	0.6993	0.6889
	High Dose Brensocatib	0.9808	0.9989	0.9585
Wistar	Low Dose Brensocatib	0.7801	0.9986	0.4786
	Mid Dose Brensocatib	0.4620	0.2491	0.4881
	High Dose Brensocatib	>0.9999	0.9692	0.8924