TABLE 7.

NSP percentage change from vehicle control after 1, 4, 7, 10, and 14 days of brensocatib 5 mg/kg BID treatment in C57BL/6 mice. p-values derived from Dunnett’s multiple comparison test.

	Percent change from vehicle
	NE	PR3	CatG
1-day	−28% (p = 0.0826)	−5% (p = 0.9972)	−26% (0.0727)
4-day	−59% (p < 0.0001)	−43% (p = 0.0236)	−81% (p < 0.0001)
7-day	−83% (p < 0.0001)	−85% (p < 0.0001)	−99% (p < 0.0001)
10-day	−76% (p < 0.0001)	−71% (p < 0.0001)	−93% (p < 0.0001)
14-day	−82% (p < 0.0001)	−81% (p < 0.0001)	−99% (p < 0.0001)