TABLE 8.
NSP percentage change from vehicle control after C57BL/6 mice were allowed to recover from 8-days of brensocatib treatment for 1-, 3-, 6-, 8-, and 10-days. p-values derived from Dunnett’s multiple comparison test.
| Percent change from vehicle | |||
|---|---|---|---|
| NE | PR3 | CatG | |
| 1-day | −49% (p < 0.0001) | −63% (p < 0.0001) | −93% (p < 0.0001) |
| 3-day | −4% (p = 0.9544) | −28% (p = 0.0024) | −60% (p < 0.0001) |
| 6-day | −20% (p = 0.0067) | −14% (p = 0.3753) | −14% (p = 0.2431) |
| 8-day | −2% (p = 0.9986) | +5% (p = 0.9691) | +26% (p = 0.0133) |
| 10-day | +15% (p = 0.0607) | +16% (p = 0.1549) | +38% (p < 0.0001) |