Table 2.
Pharmacokinetic parameters in patients who extended their treatment interval to a 21-day regimen.
| Parameter | Na | PK value, mean (SD) |
|---|---|---|
| Cmaxb (IU/dL) | 11 | 100.60 (12.69) |
| IRb ([IU/dL]/[IU/kg]) | 11 | 1.00 (0.13) |
| t1/2 (h) | 7 | 148.98 (19.62) |
| AUC0-inf (h × IU/dL) | 7 | 17 582.50 (2231.12) |
| CL (mL/h/kg) | 7 | 0.59 (0.07) |
AUC0-inf, area under the concentration time curve at time 0 extrapolated to infinity; CL, clearance; Cmax, maximum concentration; IR, incremental recovery; IU, international unit; PK, pharmacokinetic;t1/2, half-life.
a
When calculating the group means, 1 patient had 2 pharmacokinetic data points available; in this instance, the mean of the 2 values was taken.
b
Data are mean baseline–corrected for maximum concentration and incremental recovery, and all other parameters are baseline uncorrected.