Table 2.
Absolute Monocyte Count and Interstitial Lung Abnormalities Progression
| Model | AGES-Reykjavik |
||
|---|---|---|---|
| No. Participants | OR for ILA Progression (95% CI) | P Value | |
| Model 1 | 1,659 | 1.3 (1.1–1.5) | <0.001 |
| Model 2 | 1,659 | 1.2 (1.0–1.3) | 0.04 |
| Smoking status | |||
| Nonsmoker | 751 | 1.1 (0.8–1.4) | 0.67 |
| Smoker | 908 | 1.2 (1.0–1.4) | 0.04 |
| Sex | |||
| Female | 966 | 1.3 (1.0–1.5) | 0.03 |
| Male | 693 | 1.1 (0.9–1.3) | 0.38 |
Definition of abbreviations: AGES = Age, Gene/Environment Susceptibility Study; CI = confidence interval; ILA = interstitial lung abnormalities; OR = odds ratio.
Model 1: Unadjusted. Model 2: Adjusted for age, sex, smoking status, cigarette pack-years, and body mass index. Stratified models include interaction term “effect modifier × monocyte count.” P value for smoking interaction = 0.42. P value for sex interaction = 0.28. Results are reported per 1-SD increment of absolute monocyte count.