Table 1.

Summary of clinical features in affected males from two families with SAT1 mutations.

Patient (gender)	Family (ethnic origin)	Age of onset	Brief clinical symptoms	Renal disorder	Immunological disorder
3 (M)	Family #1 (AA)	6 y	Malar rash, Nonerosive arthritis, Serositis, Pleuritis and Pericarditis	Cellular casts	ANA, anti-dsDNA, anti-Smith, anti-CL, anti-Ro, anti-RNP; Low C3, C4
4 (M)	Family #1 (AA)	7 y	Malar rash, Photosensitivity, Leukopenia, Lymphopenia	Proteinuria	ANA, anti-dsDNA, anti-Smith, Anti-CL, anti-Ro, anti-RNP; Low C3
7 (M)	Family #2 (AA)	12 y	Nonerosive arthritis, Anemia, Fatigue	Proteinuria; Renal biopsy: membranous proliferative GN (Class V)	ANA, anti-dsDNA; Low C3, C4
		14 y		Renal failure
8 (M)	Family #2 (AA)	8 y	CNS lupus, Nonerosive arthritis	Proteinuria; Renal biopsy: focal proliferative GN (Class III)	Anti-dsDNA; ANA > 1:1280
		14 y	Vasculitis affecting the eyes, 2/2	Diffuse lupus glomerulonephritis with crescents	Anti-dsDNA, anti-Smith, anti-RNP, anti-β2GPI and anti-CL

Abbreviation: M: male; AA: African American; y: Years old; GN: Glomerulonephritis; anti-dsDNA: anti-double stranded DNA; ANA: Anti-Nuclear Antibody; anti-CL: anti-cardiolipin; anti-RNP: anti- antinuclear ribonucleoprotein; anti-β2GPI: anti-β2 glycoprotein I; CNS: central nervous system.