Table 3.
Associations of Omega-3 intake on the risk of incident liver disease in UKB.
| No. with event/ total No.* | Hazard ratio (95% CI) | p-value | |
|---|---|---|---|
| Incident liver disease ** | |||
| In Men*** | 157/15,373 | 0.722 (0.611 to 0.854) | 1.4e-04 |
| In Women*** | 193/22,748 | 0.715 (0.613 to 0.834) | 2.0e-05 |
| PNPLA3 rs738409 (wt) | 184/23,023 | 0.679 (0.580 to 0.793) | 1.0e-06 |
| PNPLA3 rs738409 (het) | 122/12,496 | 0.729 (0.602 to 0.884) | 1.0e-03 |
| PNPLA3 rs738409 (hom) | 33/1,698 | 0.96 (0.66 to 1.41) | 0.84 |
| TM6SF2 rs58542926 (wt) | 285/31,817 | 0.722 (0.636 to 0.818) | 3.8e-07 |
| TM6SF2 rs58542926 (het) | 53/5,127 | 0.76 (0.57 to 1.01) | 0.06 |
| TM6SF2 rs58542926 (hom) | <5/213 | 0.38 (0.08 to 1.74) | 0.21 |
| HSD17B13 rs72613567 (wt) | 173/19,536 | 0.686 (0.584 to 0.805) | 4.0e-06 |
| HSD17B13 rs72613567 (het) | 141/14,849 | 0.775 (0.647 to 0.927) | 5.3e-03 |
| HSD17B13 rs72613567 (hom) | 23/2,719 | 0.610 (0.393 to 0.949) | 2.8e-02 |
| MTARC1 rs2642438 (wt) | 165/18,456 | 0.710 (0.602 to 0.837) | 4.6e-05 |
| MTARC1 rs2642438 (het) | 147/15,407 | 0.738 (0.619 to 0.880) | 7.1e-04 |
| MTARC1 rs2642438 (hom) | 27/3322 | 0.660 (0.439 to 0.992) | 4.6e-02 |
*For sensitivity analyses, only individuals taking Omega-3 were referred to, with hazard ratios and p-values calculated consistently compared to individuals not taking Omega-3. **Incident Liver Disease is defined as new onset Liver Disease K70-K77 after Baseline examination. ***Sex was excluded from the covariates. Bold values are significant (p-value < 0.05).