Table 1.
Cost Per Day of Individual Azoles Based on Medicare Claims Payments and List Costs for the Typical Daily Dose
| Azole | Median Cost/Day 2020 |
Average Annual Inflation Rate 2013*–2020 |
Typical Dose | WAC Cost Per Day Based On Typical Dose |
|---|---|---|---|---|
| Fluconazole | $1.62 | 2.00% | 200 mg every 24 hours | $0.41–3.00 |
| Isavuconazole | $188.30 | 8.37% | 372 mg every 24 hours | $214 |
| Itraconazole | $7.40 | −11.01% | 200 mg every 12 hours | $6.66–30.88 |
| Posaconazole | $147.75 | −4.05% | 300 mg every 24 hours | $48.50–60.00 |
| Voriconazole | $16.64 | −17.11% | 200 mg every 12 hours | $15.00–41.00 |
Abbreviations: WAC, wholesale acquisition cost.
NOTES: *Inflation rate was calculated from 2014 to 2020 for posaconazole because the delayed release tablet was approved in November of 2013. Inflation rate for isavuconazole was from 2015 to 2020 given the approval of that drug in 2015. A negative value for inflation rate denotes costs trending downward. The WAC (March 18, 2023) was obtained from the Red Book, Micromedex. The inflation rate is calculated as [(2020 cost/Original Cost)1/y −1] × 100%, where y is the time interval in years.