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. 2023 Jul 19;50(3):166. doi: 10.3892/or.2023.8603

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Copyright: © Lukoseviciute et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effect of combined PI3K and CDK4/6 inhibitors WEE1 G2 checkpoint kinase and PARP inhibitors on neuroblastoma cell lines. Upon combination of BYL and PD, CIs were calculated by (A) highest single agent and (B) median effect method after 48 h. When combining MK together with BMN, CIs were calculated by (C) highest single agent and (D) median effect method after 48 h. CI>1.45 suggests antagonism, 0.75<CI>1.45 additive, and CI<0.75 synergistic effects. o indicates CI>2, which implies a negative combination effect. CI, combination index; PD, PD-0332991; BYL, BYL719; BMN, BMN673; MK, MK-1775; PARP, poly-ADP-ribose-polymerase.