TABLE 2.
Characteristics of patients with or without EMVI on baseline MRI
| Characteristic (n = 175) | No. of patients (%) |
p valuea | |
|---|---|---|---|
| Without EMVI (n = 140) | With EMVI (n = 35) | ||
|
| |||
| Ageb | 54 (26–80) yr | 51 (31–75) yr | 0.11 |
| Female sex | 63 (45) | 15 (43) | 0.80 |
| Tumor locationc | 0.30 | ||
| Lower rectum | 64 (46) | 12 (34) | |
| Middle rectum | 67 (48) | 19 (54) | |
| Upper rectum | 9 (6) | 4 (11) | |
| Clinical T classification | 0.006 | ||
| 2 | 11 (8) | 0 | |
| 3 | 122 (87) | 28 (80) | |
| 4 | 7 (5) | 7 (20) | |
| Clinical N classification | 0.40 | ||
| Node negative | 34 (24) | 6 (17) | |
| Node positive | 106 (76) | 29 (83) | |
| Charlson Comorbidity Index | 0.20 | ||
| 0 | 48 (34) | 18 (51) | |
| 1 | 39 (28) | 8 (23) | |
| 2+ | 53 (38) | 9 (26) | |
| Neoadjuvant therapyd | >0.90 | ||
| Consolidation | 2 (1) | 0 | |
| Induction | 138 (99) | 35 (100) | |
| Pathologic T classification | <0.001 | ||
| 0 | 41 (29) | 2 (6) | |
| 1 | 11 (8) | 1 (3) | |
| 2 | 46 (33) | 3 (9) | |
| 3 | 42 (30) | 28 (80) | |
| 4 | 0 | 1 (3) | |
| Pathologic N classification | 0.022 | ||
| Node negative | 107 (76) | 20 (57) | |
| Node positive | 33 (24) | 15 (43) | |
| pCR | 0.018 | ||
| No | 113 (81) | 34 (97) | |
| Yes | 27 (19) | 1 (3) | |
| Tumor gradee | >0.90 | ||
| Well differentiated | 6 (6) | 1 (3) | |
| Moderately differentiated | 82 (83) | 29 (88) | |
| Poorly differentiated | 11 (11) | 3 (9) | |
| Perineural invasione | <0.001 | ||
| No | 115 (85) | 19 (54) | |
| Yes | 20 (15) | 16 (46) | |
| Positive margin | 0.50 | ||
| No | 138 (99) | 34 (97) | |
| Yes | 2 (1) | 1 (3) | |
EMVI extramural venous invasion, pCR pathologic complete response
a
Pearson chi-square test, Fisher exact test, or Wilcoxon rank sum test.
b
Mean (minimum–maximum).
c
Grouped based on centimeters from the anal verge
d
Consolidation is chemoradiotherapy followed by systemic chemotherapy; induction is systemic chemotherapy followed by chemoradiotherapy.
e
Numbers reflect missing data