TABLE 3.
Multivariable analyses of DFS and OS
| Characteristic | Hazard ratio (95% CI) |
|
|---|---|---|
| DFS | OS | |
|
| ||
| Age | 1.01 (0.95–1.06) | 1.11 (0.99–1.25) |
| Sex | ||
| Female | Reference | Reference |
| Male | 0.97 (0.47–1.99) | 1.22 (0.40–3.71) |
| Clinical T classification | ||
| 2 | Reference | Reference |
| 3 | 2.36 (0.30–18.6) | 0.29 (0.03–2.74) |
| 4 | 4.66 (0.51–42.4) | 0.56 (0.04–7.83) |
| Clinical N classification | ||
| Node negative | Reference | Reference |
| Node positive | 0.31 (0.15–0.66) | 0.62 (0.18–2.08) |
| Charlson Comorbidity Index | ||
| 0 | Reference | Reference |
| 1 | 0.62 (0.21–1.81) | 0.38 (0.05–2.74) |
| 2+ | 0.67 (0.15–3.03) | 0.18 (0.01–5.02) |
| Tumor locationa | ||
| Lower rectum | Reference | Reference |
| Middle rectum | 1.05 (0.50–2.21) | 1.59 (0.42–6.12) |
| Upper rectum | 2.01 (0.65–6.16) | 4.82 (0.84–27.6) |
| EMVI on baseline MRI | ||
| Yes | Reference | Reference |
| No | 4.24 (2.08–8.66) | 6.04 (1.81–20.10) |
DFS disease-free survival, OS overall survival, CI confidence interval, EMVI extramural venous invasion Bold indicates statistical significance
a
Grouped based on centimeters from the anal verge