Skip to main content
. 2023 Aug 2;17(1):92. doi: 10.1186/s13065-023-00990-7

Table 9.

Comparison of greenness report between the suggested and reported HPLC methods adopting NEMI method [16]

Mixture Method Mobile phase Run time (min.) Flow rate (mL/min.) Waste (g/run)
Run time × flow rate [10]		 Greenness profile**
Paracetamol and Dantrolene Reported HPLC method [19]

Methanol: water (55:45, v/v)

pH 3 with aqueous formic acid

 12 1.0 12 graphic file with name 13065_2023_990_Figa_HTML.gif
Paracetamol and Dantrolene

Reported HPLC method

[20]

Methanol: potassium dihydrogen phosphate (50:50 v/v)

pH 3.5 by phosphoric acid

 9 1.0 9 graphic file with name 13065_2023_990_Figb_HTML.gif
Paracetamol and Dantrolene Proposed HPLC method

Ethanol: water

(40:60)

pH 4.5 by phosphoric acid

 6 0.8 4.8 graphic file with name 13065_2023_990_Figc_HTML.gif

**Four key terms are referred to PBT (persistent, bio-accumulative, and toxic), Hazardous, Corrosive, and Waste