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. Author manuscript; available in PMC: 2023 Aug 2.
Published in final edited form as: Arch Toxicol. 2022 Sep 9;96(12):3219–3231. doi: 10.1007/s00204-022-03369-0

Fig. 5.

Fig. 5

CYP2D6-overexpressing HepG2 cells attenuate the cytotoxicity of perhexiline. EV-, CYP1A2-, CYP2C19-, CYP2D6-, and CYP3A4-overexpressing HepG2 cells were exposed to 0, 5, 7.5, and 10 μM perhexiline for 24 h. Cellular ATP contents (A) and LDH release (B) were measured as toxicity endpoints. The results shown are mean ± SD from 3 biological replicates. *p < 0.05 compared to EV control at the same concentration of perhexiline