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. Author manuscript; available in PMC: 2023 Aug 2.
Published in final edited form as: Arch Toxicol. 2022 Sep 9;96(12):3219–3231. doi: 10.1007/s00204-022-03369-0

Fig. 6.

Fig. 6

Quinidine diminishes the protective effect in CYP2D6-overexpressing HepG2 cells towards perhexiline. CYP2D6-overexpressing HepG2 cells were pretreated with CYP2D6-specific inhibitor quinidine (10 μM) or control DMSO for 2 h before exposed to various concentrations of perhexiline for 24 h. Cellular ATP contents (A), cell viability (B), and LDH release (C) were measured as toxicity endpoints. The results shown are mean ± SD from 3 biological replicates. *p < 0.05 for comparison between CYP2D6-overexpressing HepG2 cells and EV control cells with DMSO pretreatment. #p < 0.05 for comparison between DMSO and quinidine pretreated CYP2D6-overexpressing HepG2 cells