Table 1.

Contribution of CYP isoforms in the formation of metabolites of perhexiline in cDNA-expressed CYP bactosomes

	M1 (trans-OH-Phx-1)	M2	M3 (trans-OH-Phx-2)	M4	M5 (cis-OH-Phx)	M6
EV	0	0	0	0	0	0.2
CYP1A2	0	0	0	2.4	0.2	7.8
CYP2C19	19.5	27.5	92.6	62.5	3.1	2.9
CYP2D6	100	100	6.5	100	100	0.6
CYP3A4	91.3	0	100	0	22.9	100

^*To demonstrate the relative contribution of individual CYP enzymes, for each metabolite, the highest abundance level observed was set to 100% and the abundance generated by other CYP enzymes was expressed as percentages accordingly. All six metabolites detected were mono-hydroxylated derivatives of perhexiline based on their exact masses